4-Fluorobenzaldehyde → (4-Fluorophenyl)[2-(trifluoromethyl)phenyl]methanol

HRID 1785706Notes

Reaction equation

[F:1][C:2]([F:12])([F:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[Mg]Br.[F:13][C:14]1[CH:21]=[CH:20][C:17]([CH:18]=[O:19])=[CH:16][CH:15]=1.FC(F)(F)C1C=C(Cl)C=CC=1C(O)C1C=CC=CC=1>>[F:1][C:2]([F:12])([F:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:18]([OH:19])[C:17]1[CH:20]=[CH:21][C:14]([F:13])=[CH:15][CH:16]=1

Participants

Reactant 3

HCID 680234-Fluorobenzaldehyde

HCID 68907806(4-Chloro-2-(trifluoromethyl)phenyl)(phenyl)methanol

HCID 178506141HCID 178506141, compound

Product 1

HCID 49963912(4-Fluorophenyl)[2-(trifluoromethyl)phenyl]methanol

Procedure

This material was prepared from 2-(trifluoromethyl)phenylmagnesium bromide (16 mmol) and 4-fluorobenzaldehyde (1.64 mL, 15 mmol) using the procedure described for compound (96) (4.27 g, 100%).

Sources & evidence

ORD record: ord-37829da8c28c4383bf0640fbec818027
Source dataset: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07504522B2

Reaction notes

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