3-(2,4'-Dichlorobenzhydryloxy)azetidine hydrochloride → 3-[2-(Trifluoromethyl)-4'-fluorobenzhydryloxy]azetidine hydrochloride

HRID 1785708Notes

Reaction equation

HRID 1785708 reaction equation
C([N:14]1[CH2:17][CH:16]([O:18][CH:19]([C:30]2[CH:35]=[CH:34][C:33]([F:36])=[CH:32][CH:31]=2)[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[C:26]([F:29])([F:28])[F:27])[CH2:15]1)(C1C=CC=CC=1)C1C=CC=CC=1.Cl.[Cl:38]C1C=CC=CC=1C(OC1CNC1)C1C=CC(Cl)=CC=1>>[ClH:38].[F:29][C:26]([F:27])([F:28])[C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=1[CH:19]([O:18][CH:16]1[CH2:17][NH:14][CH2:15]1)[C:30]1[CH:35]=[CH:34][C:33]([F:36])=[CH:32][CH:31]=1

Participants

3

Reactant 2

HCID 689023433-(2,4'-Dichlorobenzhydryloxy)azetidine hydrochlorideHCID 689032081-Benzhydryl-3-[2-(trifluoromethyl)-4'-fluorobenzhydryloxy]azetidine

Product 1

HCID 689056553-[2-(Trifluoromethyl)-4'-fluorobenzhydryloxy]azetidine hydrochlorideYield 55%

Procedure

This material was prepared from 1-benzhydryl-3-[2-(trifluoromethyl)-4′-fluorobenzyloxy]azetidine (161) (7.5 mmol) using the procedure described for compound (9). Crystallisation from DIPE-MeOH afforded the product as a white solid (1.49 g, 55%).

Workup

  1. customCrystallisation from DIPE-MeOH

Sources & evidence

ORD record
ord-94e76d7f07a041e5a96f6a5d1cb7a590
Source dataset
uspto-grants-2009_03
Patent number
US07504522B2

Reaction notes

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