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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1785708Generated: October 30, 2026

3-(2,4'-Dichlorobenzhydryloxy)azetidine hydrochloride → 3-[2-(Trifluoromethyl)-4'-fluorobenzhydryloxy]azetidine hydrochloride

https://huagongshe.com/reaction/1785708

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(2,4'-Dichlorobenzhydryloxy)azetidine hydrochlorideHCID 68902343—
Reactant1-Benzhydryl-3-[2-(trifluoromethyl)-4'-fluorobenzhydryloxy]azetidineHCID 68903208—
Product3-[2-(Trifluoromethyl)-4'-fluorobenzhydryloxy]azetidine hydrochlorideHCID 6890565555%

Reaction Steps

This material was prepared from 1-benzhydryl-3-[2-(trifluoromethyl)-4′-fluorobenzyloxy]azetidine (161) (7.5 mmol) using the procedure described for compound (9). Crystallisation from DIPE-MeOH afforded the product as a white solid (1.49 g, 55%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07504522B2
Source datasetuspto-grants-2009_03
ORD IDord-94e76d7f07a041e5a96f6a5d1cb7a590
Source noteuspto-grants-2009_03