Methyl iodide → HCID 22730461, compound

HRID 1785824Notes

Reaction equation

HRID 1785824 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][N:5]([C:8]2[CH:17]=[CH:16][C:11]([C:12]([O:14][CH3:15])=[O:13])=[CH:10][CH:9]=2)[C:4](=[O:18])[CH:3]=1.IC.[C:21]([O-])([O-])=O.[K+].[K+]>CC(C)=O>[CH3:21][O:1][C:2]1[CH:7]=[CH:6][N:5]([C:8]2[CH:17]=[CH:16][C:11]([C:12]([O:14][CH3:15])=[O:13])=[CH:10][CH:9]=2)[C:4](=[O:18])[CH:3]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 54705574HCID 54705574, compound

Product 1

HCID 22730461HCID 22730461, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A solution of Example 296A (2.3 g, 10 mmol) in acetone (300 mL) was treated with iodomethane (5 mL) and K2CO3 (15 g), heated to reflux for 18 hours, and filtered. The silical gel with 4:1 hexanes/ethyl acetate to provide the desired product. MS (ESI) m/e 260 (M+H)+.

Workup

  1. temperatureheated
  2. temperatureto reflux for 18 hours
  3. filtrationfiltered

Sources & evidence

ORD record
ord-156ccbcb7acd4acaad4d8aba07473982
Source dataset
uspto-grants-2009_03
Patent number
US07504512B2

Reaction notes

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