Phosphorus oxychloride → HCID 22730052, compound

HRID 1785832Notes

Reaction equation

HRID 1785832 reaction equation
O[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[C:5]([C:12]3[CH:21]=[CH:20][C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:14][CH:13]=3)[CH:6]=[CH:7][CH:8]=2)[N:3]=1.O=P(Cl)(Cl)[Cl:24]>>[Cl:24][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[C:5]([C:12]3[CH:21]=[CH:20][C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:14][CH:13]=3)[CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178497466HCID 178497466, compound

Product 1

HCID 22730052HCID 22730052, compound

Procedure

A mixture of Example 336B (1.76 g, 6.3 mmol) in POCl3 (50 mL) was heated to reflux for 30 minutes and concentrated. The concentrate was purified through a silica gel pad with 4:1 hexanes/ethyl acetate to provide the desired product. MS (ESI) m/e 298 ( M+H)+.

Workup

  1. temperatureto reflux for 30 minutes
  2. concentrationconcentrated
  3. customThe concentrate was purified through a silica gel pad with 4:1 hexanes/ethyl acetate

Sources & evidence

ORD record
ord-145d480f0a8147188c550d008a62933f
Source dataset
uspto-grants-2009_03
Patent number
US07504512B2

Reaction notes

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