Ethyl 4-piperidinecarboxylate → HCID 57595450, compound

HRID 1786062Notes

Reaction equation

HRID 1786062 reaction equation
C(OC([CH:6]1[CH2:11][CH2:10][N:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([N:20]3[C:29]4[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=4)[C@H:23]([N:30]([C:38](=[O:40])[CH3:39])[C:31]4[CH:36]=[CH:35][C:34]([Cl:37])=[CH:33][CH:32]=4)[CH2:22][C@@H:21]3[CH3:41])=[O:19])=[CH:14][CH:13]=2)[CH2:8][CH2:7]1)=O)C.[CH2:42]([O:44][C:45](C1CCNCC1)=[O:46])[CH3:43]>>[CH2:42]([O:44][C:45]([CH:7]1[CH2:6][CH2:11][CH2:10][N:9]([C:12]2[CH:13]=[CH:14][C:15]([C:18]([N:20]3[C:29]4[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=4)[C@H:23]([N:30]([C:38](=[O:40])[CH3:39])[C:31]4[CH:36]=[CH:35][C:34]([Cl:37])=[CH:33][CH:32]=4)[CH2:22][C@@H:21]3[CH3:41])=[O:19])=[CH:16][CH:17]=2)[CH2:8]1)=[O:46])[CH3:43]

Participants

3

Reactant 2

HCID 70770Ethyl 4-piperidinecarboxylateHCID 57595389HCID 57595389, compound

Product 1

HCID 57595450HCID 57595450, compound

Procedure

(2S,4R)-1-(4-{4-[Acetyl-(4-chloro-phenyl)-amino]-2-methyl-3,4-dihydro-2H-quinoline-1-carbonyl}-phenyl)-piperidine-3-carboxylic acid ethyl ester was prepared following the procedure for (2S,4R)-1-(4-{4-[Acetyl-(4-chloro-phenyl)-amino]-2-methyl-3,4-dihydro-2H-quinoline-1-carbonyl}-phenyl)-piperidine-4-carboxylic acid ethyl ester, substituting piperidine-3-carboxylic acid ethyl ester for piperidine-4-carboxylic acid ethyl ester to yield the product.

Workup

  1. customto yield the product

Sources & evidence

ORD record
ord-da5ab7e65d354a46b02cf5f73b6d7f4f
Source dataset
uspto-grants-2009_03
Patent number
US07504508B2

Reaction notes

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