3-Chloro-2-methylbenzenesulfonyl chloride → 3-Chloro-N-(2-cyclobutyl-pyrimidin-4-yl)-2-methyl-benzenesulfonamide

HRID 1786129Notes

Reaction equation

HRID 1786129 reaction equation
[CH:1]1([C:5]2[N:10]=[C:9]([NH2:11])[CH:8]=[CH:7][N:6]=2)[CH2:4][CH2:3][CH2:2]1.[Cl:12][C:13]1[C:14]([CH3:23])=[C:15]([S:19](Cl)(=[O:21])=[O:20])[CH:16]=[CH:17][CH:18]=1>>[Cl:12][C:13]1[C:14]([CH3:23])=[C:15]([S:19]([NH:11][C:9]2[CH:8]=[CH:7][N:6]=[C:5]([CH:1]3[CH2:2][CH2:3][CH2:4]3)[N:10]=2)(=[O:21])=[O:20])[CH:16]=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 5227343-Chloro-2-methylbenzenesulfonyl chlorideHCID 457875782-Cyclobutylpyrimidin-4-amine

Product 1

HCID 115736263-Chloro-N-(2-cyclobutyl-pyrimidin-4-yl)-2-methyl-benzenesulfonamide

Procedure

This compound was obtained according to example 2, step B] from 2-cyclobutyl-pyrimidin-4-ylamine (0.15 g), and 3-chloro-2-methyl-benzenesulfonyl chloride (0.27 g) as a light brown solid (47 mg). MS (ESI): 338.1 (MH+).

Workup

  1. customThis compound was obtained

Sources & evidence

ORD record
ord-c1ad65b5ed734f73a3282ffb2f81586a
Source dataset
uspto-grants-2009_03
Patent number
US07507733B2

Reaction notes

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