3-Ethoxy-2-propenenitrile → HCID 67175973, compound

HRID 1786132Notes

Reaction equation

HRID 1786132 reaction equation
Cl.[CH2:2]([C:4]1[S:5][CH:6]=[C:7]([C:9]([NH2:11])=[NH:10])[N:8]=1)[CH3:3].[O-]CC.[Na+].C(O[CH:19]=[CH:20][C:21]#[N:22])C>>[CH2:2]([C:4]1[S:5][CH:6]=[C:7]([C:9]2[N:11]=[C:21]([NH2:22])[CH:20]=[CH:19][N:10]=2)[N:8]=1)[CH3:3]

Participants

4

Reactant 3

HCID 436013-Ethoxy-2-propenenitrileHCID 2723922Sodium ethoxideHCID 67176564HCID 67176564, compound

Product 1

HCID 67175973HCID 67175973, compound

Procedure

This material was obtained as described in example 2, step A] from 2-ethyl-thiazole-4-carboxamidine hydrochloride (3 g) by treatment with sodium ethoxide (3.13 mL of a 5.4 M solution) and 3-ethoxyacrylonitrile (1.73 mL) to give 2-(2-ethyl-thiazol-4-yl)-pyrimidin-4-ylamine (2.56 g) as a brown solid. MS (ESI): 193.3 (MH+).

Workup

  1. customThis material was obtained

Sources & evidence

ORD record
ord-def97b4b51ed45a39e0d649f96977a22
Source dataset
uspto-grants-2009_03
Patent number
US07507733B2

Reaction notes

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