Trifluoroacetic acid → HCID 136042954, compound

HRID 1786145Notes

Reaction equation

HRID 1786145 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]2[N:14]3[N:15]=[CH:16][CH:17]=[C:13]3[N:12](C(OC(C)(C)C)=O)[C:11]([CH3:25])=[C:10]2[C:26](=[O:40])[N:27]([S:29]([C:32]2[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[CH:34][CH:33]=2)(=[O:31])=[O:30])[CH3:28])[CH:5]=[CH:6][C:7]=1[Cl:8].C(O)(C(F)(F)F)=O>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]2[N:14]3[N:15]=[CH:16][CH:17]=[C:13]3[NH:12][C:11]([CH3:25])=[C:10]2[C:26]([N:27]([S:29]([C:32]2[CH:33]=[CH:34][C:35]([O:38][CH3:39])=[CH:36][CH:37]=2)(=[O:31])=[O:30])[CH3:28])=[O:40])[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68828937HCID 68828937, compound

Product 1

HCID 136042954HCID 136042954, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a mixture of the product obtained from Step C (60 mg, 0.1 mmol) in CH2Cl2 (5.0 mL) at room temperature under N2 was added TFA (5.0 mL). The mixture was stirred for 1.5 h. LC-MS indicated the completion of reaction. Solvent was evaporated, and the mixture was purified by reverse phase HPLC (acetonitrile/water). The desired product was obtained as white solid. LC-MS found: (M+1)+=507.2.

Workup

  1. customthe completion of reaction
  2. customSolvent was evaporated
  3. customthe mixture was purified by reverse phase HPLC (acetonitrile/water)

Sources & evidence

ORD record
ord-89f7734614894818964308a5f87de7e4
Source dataset
uspto-grants-2009_03
Patent number
US07507730B2

Reaction notes

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