Hydrazine hydrate (1:1) → HCID 12993142, compound

HRID 1786163Notes

Reaction equation

HRID 1786163 reaction equation
O=C1C2C(=CC=CC=2)C(=O)[N:3]1[CH2:12][CH2:13][C:14]1([NH:17][C:18](=[O:24])[O:19][C:20]([CH3:23])([CH3:22])[CH3:21])[CH2:16][CH2:15]1.O.NN>C(O)C>[NH2:3][CH2:12][CH2:13][C:14]1([NH:17][C:18](=[O:24])[O:19][C:20]([CH3:22])([CH3:21])[CH3:23])[CH2:15][CH2:16]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 12993141HCID 12993141, compound

Product 1

HCID 12993142HCID 12993142, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 4.57 g (13.83 mmol) of tert-butyl 1-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]cyclopropylcarbamate in 80 ml of ethanol was added 3.36 ml (69.16 mmol) of hydrazine hydrate and the resulting mixture was heated under reflux for 16 h. The mixture was filtered and washed with diethyl ether. The filtrate was evaporated to dryness to give 2.3 g of pure compound as an orange oil.

Workup

  1. temperaturethe resulting mixture was heated
  2. temperatureunder reflux for 16 h
  3. filtrationThe mixture was filtered
  4. washwashed with diethyl ether
  5. customThe filtrate was evaporated to dryness

Sources & evidence

ORD record
ord-176c32185fd343709c7037315fa0835c
Source dataset
uspto-grants-2009_03
Patent number
US07507743B2

Reaction notes

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