9-chloro-2-cyclopropyl-6H-[1,2,4]triazolo[1,5-c]quinazolin-5-one → HCID 178494724, compound

HRID 1786171Notes

Reaction equation

HRID 1786171 reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][C:9]2[NH:8]C(=O)[N:6]3[N:13]=[C:14]([CH2:16][O:17][CH3:18])[N:15]=[C:5]3[C:4]=2[CH:3]=1.ClC1C=CC2NC(=O)N3N=C(C4CC4)N=C3C=2C=1>>[Cl:1][C:2]1[CH:11]=[CH:10][C:9]([NH2:8])=[C:4]([C:5]2[NH:6][N:13]=[C:14]([CH2:16][O:17][CH3:18])[N:15]=2)[CH:3]=1

Participants

3

Reactant 2

HCID 1363323169-chloro-2-cyclopropyl-6H-[1,2,4]triazolo[1,5-c]quinazolin-5-oneHCID 1363478699-Chloro-2-methoxymethyl-6H-[1,2,4]triazolo[1,5-c]quinazolin-5-one

Product 1

HCID 178494724HCID 178494724, compoundYield 92.3%

Procedure

As described for example 1b) 9-chloro-2-methoxymethyl-6H-[1,2,4]triazolo[1,5-c]quinazolin-5-one (73.4 g, 277 mmol), instead of 9-chloro-2-cyclopropyl-6H-[1,2,4]triazolo[1,5-c]quinazolin-5-one, was converted to the title compound (61.0 g, 92%) which was obtained as a brown solid. MS: m/e=238.9 [M+H]+.

Sources & evidence

ORD record
ord-572e832a6c0e4cea9e047c688cfc995b
Source dataset
uspto-grants-2009_03
Patent number
US07507729B2

Reaction notes

Loading…