9-chloro-2-cyclopropyl-6H-[1,2,4]triazolo[1,5-c]quinazolin-5-one → HCID 178494721, compound

HRID 1786175Notes

Reaction equation

HRID 1786175 reaction equation
[Br:1][C:2]1[CH:11]=[CH:10][C:9]2[NH:8]C(=O)[N:6]3[N:13]=[C:14]([CH2:16][O:17][CH3:18])[N:15]=[C:5]3[C:4]=2[CH:3]=1.ClC1C=CC2NC(=O)N3N=C(C4CC4)N=C3C=2C=1>>[Br:1][C:2]1[CH:11]=[CH:10][C:9]([NH2:8])=[C:4]([C:5]2[NH:6][N:13]=[C:14]([CH2:16][O:17][CH3:18])[N:15]=2)[CH:3]=1

Participants

3

Reactant 2

HCID 1363323169-chloro-2-cyclopropyl-6H-[1,2,4]triazolo[1,5-c]quinazolin-5-oneHCID 1363323289-Bromo-2-methoxymethyl-6H-[1,2,4]triazolo[1,5-c]quinazolin-5-one

Product 1

HCID 178494721HCID 178494721, compoundYield 99.8%

Procedure

As described for example 1b) 9-bromo-2-methoxymethyl-6H-[1,2,4]triazolo[1,5-c]quinazolin-5-one (20.9 g, 67.6 mmol), instead of 9-chloro-2-cyclopropyl-6H-[1,2,4]triazolo[1,5-c]quinazolin-5-one, was converted to the title compound (19.1 g, 99%) which was obtained as an off-white solid. MS: m/e=282.7/284.7 [M+H]+.

Sources & evidence

ORD record
ord-a04a2da259b64d18a20cf3563a9b9544
Source dataset
uspto-grants-2009_03
Patent number
US07507729B2

Reaction notes

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