HCID 178494720, compound → 9-Bromo-2-methoxymethyl-6H-1,3,3a,6-tetraaza-benzo[e]azulen-5-one

HRID 1786176Notes

Reaction equation

HRID 1786176 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([Br:12])=[CH:8][C:7]=1[C:13]1[NH:14][N:15]=[C:16]([CH2:18][O:19][CH3:20])[N:17]=1)=[O:4].ClCC(NC1C=CC(Cl)=CC=1C1NN=C(COC)N=1)=O>>[Br:12][C:9]1[CH:10]=[CH:11][C:6]2[NH:5][C:3](=[O:4])[CH2:2][N:14]3[C:13](=[N:17][C:16]([CH2:18][O:19][CH3:20])=[N:15]3)[C:7]=2[CH:8]=1

Participants

3

Reactant 2

HCID 178494720HCID 178494720, compoundHCID 178494723HCID 178494723, compound

Product 1

HCID 1363323189-Bromo-2-methoxymethyl-6H-1,3,3a,6-tetraaza-benzo[e]azulen-5-oneYield 68%

Procedure

As described for example 4d) 2-chloro-N-[4-bromo-2-(5-methoxymethyl-2H-[1,2,4]triazol-3-yl)-phenyl]-acetamide (20.6 g, 57.3 mmol), instead of 2-chloro-N-[4-chloro-2-(5-methoxymethyl-2H-[1,2,4]triazol-3-yl)-phenyl]-acetamide, was converted to the title compound (12.6 g, 68%) which was obtained as an off-white solid. MS: m/e=322.0/324.0 [M+H]+.

Sources & evidence

ORD record
ord-927f268940ee4dfcabfc932e7e0c3b97
Source dataset
uspto-grants-2009_03
Patent number
US07507729B2

Reaction notes

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