Hydrazine hydrate (1:1) → 2-Oxo-1(2H)-pyridineacetic acid hydrazide

Participants

Reaction Steps

As described for example 112a, (2-oxo-2H-pyridin-1-yl)-acetic acid ethyl ester (Begley, William J. et. al. Journal of the Chemical Society, Perkin Transactions 1 (1981), (9), 2620-4) in ethanol was reacted with hydrazine hydrate (1.1 equivalents) at 60° C. for 36 h. The mixture was cooled to rt and the precipitated product was filtered off and dried to afford the title compound as a white solid (yield: 78%). MS: m/e=168.2 [M+H]+.

Provenance & Evidence