Hydrazine hydrate (1:1) → 2-Oxo-1(2H)-pyridineacetic acid hydrazide

HRID 1786194Notes

Reaction equation

HRID 1786194 reaction equation
C([O:3][C:4](=O)[CH2:5][N:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]1=[O:12])C.O.[NH2:15][NH2:16]>C(O)C>[O:12]=[C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][N:6]1[CH2:5][C:4]([NH:15][NH2:16])=[O:3]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 9497629Ethyl 2-(2-oxopyridin-1-YL)acetate

Product 1

HCID 71309802-Oxo-1(2H)-pyridineacetic acid hydrazideYield 78%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

As described for example 112a, (2-oxo-2H-pyridin-1-yl)-acetic acid ethyl ester (Begley, William J. et. al. Journal of the Chemical Society, Perkin Transactions 1 (1981), (9), 2620-4) in ethanol was reacted with hydrazine hydrate (1.1 equivalents) at 60° C. for 36 h. The mixture was cooled to rt and the precipitated product was filtered off and dried to afford the title compound as a white solid (yield: 78%). MS: m/e=168.2 [M+H]+.

Workup

  1. filtrationthe precipitated product was filtered off
  2. customdried

Sources & evidence

ORD record
ord-477da8e56cc646649a05e152319b7a14
Source dataset
uspto-grants-2009_03
Patent number
US07507729B2

Reaction notes

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