Hydrazine hydrate (1:1) → HCID 68406310, compound

HRID 1786197Notes

Reaction equation

HRID 1786197 reaction equation
C([O:3][C:4](=O)[CH2:5][C:6]1[N:7]([CH3:12])[N:8]=[C:9]([CH3:11])[CH:10]=1)C.O.[NH2:15][NH2:16]>C(O)C>[CH3:12][N:7]1[C:6]([CH2:5][C:4]([NH:15][NH2:16])=[O:3])=[CH:10][C:9]([CH3:11])=[N:8]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 67549347HCID 67549347, compound

Product 1

HCID 68406310HCID 68406310, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

As described for example 112a, (2,5-dimethyl-2H-pyrazol-3-yl)-acetic acid ethyl ester in ethanol was reacted with hydrazine hydrate (2 equivalents) at reflux for 16 h. Evaporation of all volatiles and chromatography (SiO2, dichloromethane:methanol:aq.ammonia (25%)=100:0:0 to 90:10:1) afforded the title compound as a white solid (yield: 78%). MS: m/e=169.3 [M+H]+.

Workup

  1. temperatureat reflux for 16 h
  2. customEvaporation of all volatiles and chromatography (SiO2, dichloromethane:methanol:aq.ammonia (25%)=100:0:0 to 90:10:1)

Sources & evidence

ORD record
ord-3000970f3aab44dca80e5aea02dd10b8
Source dataset
uspto-grants-2009_03
Patent number
US07507729B2

Reaction notes

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