Hydrazine hydrate (1:1) → HCID 386624, compound

HRID 1786199Notes

Reaction equation

HRID 1786199 reaction equation
C(O[C:4](=[O:11])[CH2:5][N:6]1[CH:10]=[CH:9][N:8]=[N:7]1)C.O.[NH2:13][NH2:14]>C(O)C>[N:6]1([CH2:5][C:4]([NH:13][NH2:14])=[O:11])[CH:10]=[CH:9][N:8]=[N:7]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 10103365ETHYL 2-(1H-1,2,3-TRIAZOL-1-YL)ACETATE

Product 1

HCID 386624HCID 386624, compoundYield 73%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
4 °C

Procedure

As described for example 112a, [1,2,3]triazol-1-yl-acetic acid ethyl ester in ethanol was reacted with hydrazine hydrate (2 equivalents) and the resulting mixture heated under reflux for 3 h. The mixture was cooled to 4° C. and the precipitated product was filtered off and dried to afford the title compound as a white solid (yield: 73%). MS: m/e=141.2[M]+.

Workup

  1. temperaturethe resulting mixture heated
  2. temperatureunder reflux for 3 h
  3. filtrationthe precipitated product was filtered off
  4. customdried

Sources & evidence

ORD record
ord-df034769d2a5441a92f005e51f5705b4
Source dataset
uspto-grants-2009_03
Patent number
US07507729B2

Reaction notes

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