HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 28940100, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Ethyl bromoacetate | HCID 7748 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 1-Ethyl-2,3-piperazinedione | HCID 108812 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 28940100 | HCID 28940100 | 72% |
Reaction Steps
As described for example 119a, 1-ethyl-piperazine-2,3-dione was reacted with sodium hydride followed by reaction with ethyl bromoacetate. Aqueous workup followed by chromatography (SiO2, dichloromethane:methanol=100:0 to 94:4) afforded the title compound as a light yellow oil (yield: 72%). MS: m/e=229.4 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07507729B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-a32ab292fd514910b7c2ce46dfbb02cb |
| Source note | uspto-grants-2009_03 |