Dichloromethane → HCID 28940100, compound

HRID 1786200Notes

Reaction equation

HRID 1786200 reaction equation
[CH2:1]([N:3]1[CH2:8][CH2:7][NH:6][C:5](=[O:9])[C:4]1=[O:10])[CH3:2].[H-].[Na+].Br[CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16].ClCCl>CO>[CH2:18]([O:17][C:15](=[O:16])[CH2:14][N:6]1[CH2:7][CH2:8][N:3]([CH2:1][CH3:2])[C:4](=[O:10])[C:5]1=[O:9])[CH3:19]

Participants

6

Reactant 4

HCID 6344DichloromethaneHCID 7748Ethyl bromoacetateHCID 24758Sodium hydrideHCID 1088121-Ethyl-2,3-piperazinedione

Product 1

HCID 28940100HCID 28940100, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

As described for example 119a, 1-ethyl-piperazine-2,3-dione was reacted with sodium hydride followed by reaction with ethyl bromoacetate. Aqueous workup followed by chromatography (SiO2, dichloromethane:methanol=100:0 to 94:4) afforded the title compound as a light yellow oil (yield: 72%). MS: m/e=229.4 [M+H]+.

Sources & evidence

ORD record
ord-a32ab292fd514910b7c2ce46dfbb02cb
Source dataset
uspto-grants-2009_03
Patent number
US07507729B2

Reaction notes

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