反应详情

As described for example 112a, (4-ethyl-2,3-dioxo-piperazin-1-yl)-acetic acid ethyl ester in ethanol was reacted with hydrazine hydrate (1.2 equivalents) and the resulting mixture heated under reflux for 16 h. The precipitated product was filtered off and dried to afford the title compound as a white solid (yield: 77%). MS: m/e=215.4 [M+H]+.

1. temperaturethe resulting mixture heated
2. temperatureunder reflux for 16 h
3. filtrationThe precipitated product was filtered off
4. customdried