Hydrazine hydrate (1:1) → HCID 55027973, compound

HRID 1786201Notes

Reaction equation

HRID 1786201 reaction equation
C(O[C:4](=[O:16])[CH2:5][N:6]1[CH2:11][CH2:10][N:9]([CH2:12][CH3:13])[C:8](=[O:14])[C:7]1=[O:15])C.O.[NH2:18][NH2:19]>C(O)C>[CH2:12]([N:9]1[CH2:10][CH2:11][N:6]([CH2:5][C:4]([NH:18][NH2:19])=[O:16])[C:7](=[O:15])[C:8]1=[O:14])[CH3:13]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 28940100HCID 28940100, compound

Product 1

HCID 55027973HCID 55027973, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

As described for example 112a, (4-ethyl-2,3-dioxo-piperazin-1-yl)-acetic acid ethyl ester in ethanol was reacted with hydrazine hydrate (1.2 equivalents) and the resulting mixture heated under reflux for 16 h. The precipitated product was filtered off and dried to afford the title compound as a white solid (yield: 77%). MS: m/e=215.4 [M+H]+.

Workup

  1. temperaturethe resulting mixture heated
  2. temperatureunder reflux for 16 h
  3. filtrationThe precipitated product was filtered off
  4. customdried

Sources & evidence

ORD record
ord-12146869560145d38e0dc3c000add4d4
Source dataset
uspto-grants-2009_03
Patent number
US07507729B2

Reaction notes

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