Hydrazine hydrate (1:1) → HCID 67549341, compound

HRID 1786202Notes

Reaction equation

HRID 1786202 reaction equation
C[O:2][C:3](=O)[CH2:4][C:5]1[CH:9]=[CH:8][O:7][N:6]=1.O.[NH2:12][NH2:13]>C(O)C>[O:7]1[CH:8]=[CH:9][C:5]([CH2:4][C:3]([NH:12][NH2:13])=[O:2])=[N:6]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 54530476146098-75-1

Product 1

HCID 67549341HCID 67549341, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

As described for example 112a, isoxazol-3-yl-acetic acid methyl ester in ethanol was reacted with hydrazine hydrate (2 equivalents) at rt for 16 h. After evaporation of the solvent the residue was chromatographed (SiO2, dichloromethane:methanol:aq.ammonia (25%)=100:0:0 to 90:10:1) to afford the title compound as a white solid (yield: 78%). MS: m/e=142.1 [M+H]+.

Workup

  1. customAfter evaporation of the solvent the residue
  2. customwas chromatographed (SiO2, dichloromethane:methanol:aq.ammonia (25%)=100:0:0 to 90:10:1)

Sources & evidence

ORD record
ord-7c74e8da66e24b51963388efc6012b76
Source dataset
uspto-grants-2009_03
Patent number
US07507729B2

Reaction notes

Loading…