Hydrazine hydrate (1:1) → [1,2,3]Triazol-2-yl-acetic acid hydrazide

HRID 1786203Notes

Reaction equation

HRID 1786203 reaction equation
C(O[C:4](=[O:11])[CH2:5][N:6]1[N:10]=[CH:9][CH:8]=[N:7]1)C.O.[NH2:13][NH2:14]>C(O)C>[N:10]1[N:6]([CH2:5][C:4]([NH:13][NH2:14])=[O:11])[N:7]=[CH:8][CH:9]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 10329488Ethyl 2-(2H-1,2,3-triazol-2-YL)acetate

Product 1

HCID 59347478[1,2,3]Triazol-2-yl-acetic acid hydrazideYield 68%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

As described for example 112a, [1,2,3]triazol-2-yl-acetic acid ethyl ester in ethanol was reacted with hydrazine hydrate (2 equivalents) and the resulting mixture heated under reflux for 3 h. The mixture was cooled to rt and the precipitated product was filtered off and dried to afford the title compound as a white solid (yield: 68%). MS: m/e=141.1 [M]+.

Workup

  1. temperaturethe resulting mixture heated
  2. temperatureunder reflux for 3 h
  3. filtrationthe precipitated product was filtered off
  4. customdried

Sources & evidence

ORD record
ord-8ab803f111ad4f6594fc701c9255f416
Source dataset
uspto-grants-2009_03
Patent number
US07507729B2

Reaction notes

Loading…