Hydrazine hydrate (1:1) → HCID 45122716, compound

HRID 1786209Notes

Reaction equation

HRID 1786209 reaction equation
C([O:3][C:4](=O)[CH2:5][N:6]1[CH2:10][CH2:9][O:8][C:7]1=[O:11])C.O.[NH2:14][NH2:15]>C(O)C>[O:11]=[C:7]1[N:6]([CH2:5][C:4]([NH:14][NH2:15])=[O:3])[CH2:10][CH2:9][O:8]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 12676751HCID 12676751, compound

Product 1

HCID 45122716HCID 45122716, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

As described for example 112a, (2-oxo-oxazolidin-3-yl)-acetic acid ethyl ester (Potts, Kevin T.; Bhattacharjee, Debkumar; Kanemasa, Shuji. Journal of Organic Chemistry (1980), 45(24), 4985-8.) in ethanol was reacted with hydrazine hydrate (1 equivalent) at rt for 72 h. Evaporation of all volatiles and chromatography (SiO2, dichloromethane:methanol:aq.ammonia (25%)=100:0:0 to 90:10:1) afforded the title compound as a white solid (yield: 77%). MS: m/e=160.2 [M+H]+.

Workup

  1. customEvaporation of all volatiles and chromatography (SiO2, dichloromethane:methanol:aq.ammonia (25%)=100:0:0 to 90:10:1)

Sources & evidence

ORD record
ord-3016bb3ae13d4daf9b8d7cb38c2a7512
Source dataset
uspto-grants-2009_03
Patent number
US07507729B2

Reaction notes

Loading…