Potassium Carbonate → HCID 68406810, compound

HRID 1786216Notes

Reaction equation

HRID 1786216 reaction equation
F[C:2]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[CH:6][C:3]=1[C:4]#[N:5].[CH3:12][C:13]1[N:14]=[CH:15][NH:16][CH:17]=1.C(=O)([O-])[O-].[K+].[K+]>>[CH3:11][O:10][C:7]1[CH:8]=[CH:9][C:2]([N:16]2[CH:17]=[C:13]([CH3:12])[N:14]=[CH:15]2)=[C:3]([CH:6]=1)[C:4]#[N:5]

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 27745462-Fluoro-5-methoxybenzonitrileHCID 178418800HCID 178418800, compound

Product 1

HCID 68406810HCID 68406810, compoundYield 72%

Procedure

As described for example 84a, 2-fluoro-5-methoxy-benzonitrile was reacted with 4-methylimidazole and potassium carbonate for 48 h at 100° C. After aqueous workup and crystallization from ethyl acetate/diisopropylether the title compound was obtained as a white solid (yield: 72%). MS: m/e=214.1 [M+H]+.

Workup

  1. customAfter aqueous workup and crystallization from ethyl acetate/diisopropylether the title compound

Sources & evidence

ORD record
ord-5daee9a71dcd4164aade629674a17850
Source dataset
uspto-grants-2009_03
Patent number
US07507729B2

Reaction notes

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