Hydrazine hydrate (1:1) → HCID 63582613, compound

HRID 1786233Notes

Reaction equation

HRID 1786233 reaction equation
C([O:3][C:4](=O)[CH2:5][N:6]1[CH:11]=[CH:10][C:9]([CH3:12])=[CH:8][C:7]1=[O:13])C.O.[NH2:16][NH2:17]>C(O)C>[CH3:12][C:9]1[CH:10]=[CH:11][N:6]([CH2:5][C:4]([NH:16][NH2:17])=[O:3])[C:7](=[O:13])[CH:8]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 62962657HCID 62962657, compound

Product 1

HCID 63582613HCID 63582613, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

As described for example 112a, (4-methyl-2-oxo-2H-pyridin-1-yl)-acetic acid ethyl ester in ethanol was reacted with hydrazine hydrate (1.2 equivalents) at rt for 72 h. The mixture was concentrated and crystallized from ethanol/diisopropylether and the compound was obtained as a white solid (yield: 94%). MS: m/e=204.3 [M+Na]+.

Workup

  1. concentrationThe mixture was concentrated
  2. customcrystallized from ethanol/diisopropylether

Sources & evidence

ORD record
ord-a56cf2991a674d33a0e86788018668c2
Source dataset
uspto-grants-2009_03
Patent number
US07507729B2

Reaction notes

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