HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl bromoacetate → HCID 67549704, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl bromoacetate | HCID 7748 | — |
| Reactant | Heptane | HCID 8900 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2(1H)-Pyridinone, 3-(trifluoromethyl)- | HCID 3678411 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 67549704 | HCID 67549704 | 2% |
Reaction Steps
As described for example 320a, 2-hydroxy-3-(trifluoromethyl)-pyridine was reacted with ethyl bromoacetate and potassium carbonate. Extractive workup followed by chromatography (SiO2, heptane:ethyl acetate=100:0 to 40:60) afforded 2 compounds. The title compound was eluted first and was obtained as a colorless liquid (yield: 2%). MS: m/e=250.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07507729B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-7cd7251ca273483383aabefc3005cce2 |
| Source note | uspto-grants-2009_03 |