Ethyl bromoacetate → HCID 67549704, compound

HRID 1786234Notes

Reaction equation

HRID 1786234 reaction equation
[OH:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][N:3]=1.Br[CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15].C(=O)([O-])[O-].[K+].[K+].CCCCCCC>C(OCC)(=O)C>[CH2:17]([O:16][C:14](=[O:15])[CH2:13][O:1][C:2]1[C:7]([C:8]([F:9])([F:11])[F:10])=[CH:6][CH:5]=[CH:4][N:3]=1)[CH3:18]

Participants

6

Reactant 4

HCID 7748Ethyl bromoacetateHCID 8900HeptaneHCID 11430Potassium CarbonateHCID 36784112(1H)-Pyridinone, 3-(trifluoromethyl)-

Product 1

HCID 67549704HCID 67549704, compoundYield 2%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

As described for example 320a, 2-hydroxy-3-(trifluoromethyl)-pyridine was reacted with ethyl bromoacetate and potassium carbonate. Extractive workup followed by chromatography (SiO2, heptane:ethyl acetate=100:0 to 40:60) afforded 2 compounds. The title compound was eluted first and was obtained as a colorless liquid (yield: 2%). MS: m/e=250.1 [M+H]+.

Workup

  1. customafforded 2 compounds
  2. washThe title compound was eluted first

Sources & evidence

ORD record
ord-7cd7251ca273483383aabefc3005cce2
Source dataset
uspto-grants-2009_03
Patent number
US07507729B2

Reaction notes

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