Hydrazine hydrate (1:1) → HCID 67549580, compound

HRID 1786235Notes

Reaction equation

HRID 1786235 reaction equation
C([O:3][C:4](=O)[CH2:5][O:6][C:7]1[C:12]([C:13]([F:16])([F:15])[F:14])=[CH:11][CH:10]=[CH:9][N:8]=1)C.O.[NH2:19][NH2:20]>C(O)C>[F:14][C:13]([F:16])([F:15])[C:12]1[C:7]([O:6][CH2:5][C:4]([NH:19][NH2:20])=[O:3])=[N:8][CH:9]=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 67549704HCID 67549704, compound

Product 1

HCID 67549580HCID 67549580, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

As described for example 112a, (3-trifluoromethyl-pyridin-2-yloxy)-acetic acid ethyl ester in ethanol was reacted with hydrazine hydrate (1.2 equivalents) at rt for 72 h. The mixture was concentrated and crystallized from ethanol/diisopropylether and the compound was obtained as a white solid (yield: 77%). MS: m/e=236.2 [M+H]+.

Workup

  1. concentrationThe mixture was concentrated
  2. customcrystallized from ethanol/diisopropylether

Sources & evidence

ORD record
ord-6cf40cf18f0643898bde32008080295c
Source dataset
uspto-grants-2009_03
Patent number
US07507729B2

Reaction notes

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