Ethyl bromoacetate → HCID 68405725, compound

HRID 1786236Notes

Reaction equation

HRID 1786236 reaction equation
[OH:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][N:3]=1.Br[CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15].C(=O)([O-])[O-].[K+].[K+]>>[CH2:17]([O:16][C:14](=[O:15])[CH2:13][N:3]1[CH:4]=[CH:5][CH:6]=[C:7]([C:8]([F:9])([F:11])[F:10])[C:2]1=[O:1])[CH3:18]

Participants

4

Reactant 3

HCID 7748Ethyl bromoacetateHCID 11430Potassium CarbonateHCID 36784112(1H)-Pyridinone, 3-(trifluoromethyl)-

Product 1

HCID 68405725HCID 68405725, compoundYield 84%

Procedure

As described in example 322a, reaction of 2-hydroxy-3-(trifluoromethyl)-pyridine with ethyl bromoacetate and potassium carbonate gave 2 products. The title compound was eluted second and was obtained as a colorless liquid (yield: 84%). MS: m/e=250.1[M+H]+.

Workup

  1. customgave 2 products
  2. washThe title compound was eluted second

Sources & evidence

ORD record
ord-278a7a96bc1d4e5eba84a67738ec2a56
Source dataset
uspto-grants-2009_03
Patent number
US07507729B2

Reaction notes

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