Hydrazine hydrate (1:1) → HCID 2821782, compound

HRID 1786239Notes

Reaction equation

HRID 1786239 reaction equation
C([O:3][C:4](=O)[CH2:5][N:6]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][CH3:13])[C:7]1=[O:14])C.O.[NH2:17][NH2:18]>C(O)C>[CH3:13][O:12][C:8]1[C:7](=[O:14])[N:6]([CH2:5][C:4]([NH:17][NH2:18])=[O:3])[CH:11]=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 67549678HCID 67549678, compound

Product 1

HCID 2821782HCID 2821782, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

As described for example 112a, (3-methoxy-2-oxo-2H-pyridin-1-yl)-acetic acid ethyl ester in ethanol was reacted with hydrazine hydrate (1.2 equivalents) at rt for 16 h. The mixture was concentrated and crystallized from ethanol/diisopropylether and the compound was obtained as a white solid (yield: 83%). MS: m/e=220.1 [M+Na]+.

Workup

  1. concentrationThe mixture was concentrated
  2. customcrystallized from ethanol/diisopropylether

Sources & evidence

ORD record
ord-009bb3719c1a404b88ea4d3fcf8de037
Source dataset
uspto-grants-2009_03
Patent number
US07507729B2

Reaction notes

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