Hydrazine hydrate (1:1) → HCID 67549919, compound

HRID 1786241Notes

Reaction equation

HRID 1786241 reaction equation
C([O:3][C:4](=O)[CH2:5][N:6]1[CH:11]=[C:10]([CH3:12])[CH:9]=[CH:8][C:7]1=[O:13])C.O.[NH2:16][NH2:17]>C(O)C>[CH3:12][C:10]1[CH:9]=[CH:8][C:7](=[O:13])[N:6]([CH2:5][C:4]([NH:16][NH2:17])=[O:3])[CH:11]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 58771148HCID 58771148, compound

Product 1

HCID 67549919HCID 67549919, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

As described for example 112a, (5-methyl-2-oxo-2H-pyridin-1-yl)-acetic acid ethyl ester in ethanol was reacted with hydrazine hydrate (1.2 equivalents) at rt for 16 h. The mixture was concentrated and crystallized from ethanol/diisopropylether and the compound was obtained as a white solid (yield: 92%). MS: m/e=204.1 [M+Na]+.

Workup

  1. concentrationThe mixture was concentrated
  2. customcrystallized from ethanol/diisopropylether

Sources & evidence

ORD record
ord-45e71c41ddfd47768b57c0412ff6d84f
Source dataset
uspto-grants-2009_03
Patent number
US07507729B2

Reaction notes

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