Hydrazine hydrate (1:1) → HCID 67549761, compound

HRID 1786245Notes

Reaction equation

HRID 1786245 reaction equation
C([O:3][C:4](=O)[CH2:5][N:6]1[C:11]([CH3:12])=[CH:10][C:9]([CH3:13])=[CH:8][C:7]1=[O:14])C.O.[NH2:17][NH2:18]>C(O)C>[CH3:13][C:9]1[CH:10]=[C:11]([CH3:12])[N:6]([CH2:5][C:4]([NH:17][NH2:18])=[O:3])[C:7](=[O:14])[CH:8]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 68406572HCID 68406572, compound

Product 1

HCID 67549761HCID 67549761, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

As described for example 112a, (4,6-dimethyl-2-oxo-2H-pyridin-1-yl)-acetic acid ethyl ester (Shusherina, N. P.; Slavyanova, O. V.; Petrova, L. K.; Levina, R. Ya. Zhurnal Organicheskoi Khimii (1972), 8(2), 387-9) in ethanol was reacted with hydrazine hydrate (1.2 equivalents) at rt for 120 h. The mixture was concentrated and crystallized from ethanol/diisopropylether and the title compound was obtained as a white solid (yield. 90%). MS: m/e=218.2 [M+Na]+.

Workup

  1. concentrationThe mixture was concentrated
  2. customcrystallized from ethanol/diisopropylether

Sources & evidence

ORD record
ord-8e6263eeedfa48e0bf3a0ae5bdc1fadb
Source dataset
uspto-grants-2009_03
Patent number
US07507729B2

Reaction notes

Loading…