Hydrazine hydrate (1:1) → HCID 45122778, compound

HRID 1786247Notes

Reaction equation

HRID 1786247 reaction equation
CO[C:3](=[O:11])[CH:4]([N:6]1[CH:10]=[N:9][CH:8]=[N:7]1)[CH3:5].O.[NH2:13][NH2:14]>C(O)CCC>[N:6]1([CH:4]([CH3:5])[C:3]([NH:13][NH2:14])=[O:11])[CH:10]=[N:9][CH:8]=[N:7]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 2768671HCID 2768671, compound

Product 1

HCID 45122778HCID 45122778, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

As described for example 112a, (rac.)-2-[1,2,4]triazol-1-yl-propionic acid methyl ester in butanol was reacted with hydrazine hydrate (1.2 equivalents) at rt for 16 h. The mixture was concentrated and triturated with toluene to afford the title compound as a white solid (yield: 91%). MS: m/e=155.0 [M]+.

Workup

  1. concentrationThe mixture was concentrated
  2. customtriturated with toluene

Sources & evidence

ORD record
ord-46c3720c154f4449815957fe8e3872cb
Source dataset
uspto-grants-2009_03
Patent number
US07507729B2

Reaction notes

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