Hydrazine hydrate (1:1) → HCID 67548783, compound

HRID 1786249Notes

Reaction equation

HRID 1786249 reaction equation
C([O:3][C:4](=O)[CH2:5][N:6]1[CH:11]=[CH:10][CH:9]=[C:8]([Br:12])[C:7]1=[O:13])C.O.[NH2:16][NH2:17]>C(O)CCC>[Br:12][C:8]1[C:7](=[O:13])[N:6]([CH2:5][C:4]([NH:16][NH2:17])=[O:3])[CH:11]=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 67549569HCID 67549569, compound

Product 1

HCID 67548783HCID 67548783, compoundYield 62%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

As described for example 112a, (3-bromo-2-oxo-2H-pyridin-1-yl)-acetic acid ethyl ester in butanol was reacted with hydrazine hydrate (1.2 equivalents) at reflux for 16 h. The precipitate was filtered and triturated with hot methanol to afford the title compound as an off-white solid (yield: 62%). MS: m/e=244.2/246.2 [M−H]−.

Workup

  1. temperatureat reflux for 16 h
  2. filtrationThe precipitate was filtered
  3. customtriturated with hot methanol

Sources & evidence

ORD record
ord-85bae26dc8f64b46b36b6910f0c0b0d1
Source dataset
uspto-grants-2009_03
Patent number
US07507729B2

Reaction notes

Loading…