Hydrazine hydrate (1:1) → HCID 45122716, compound

HRID 1786252Notes

Reaction equation

HRID 1786252 reaction equation
C([O:3][C:4](=O)[CH2:5][N:6]1[CH2:10][CH2:9][O:8][C:7]1=[O:11])C.O.[NH2:14][NH2:15]>C(O)C>[O:11]=[C:7]1[N:6]([CH2:5][C:4]([NH:14][NH2:15])=[O:3])[CH2:10][CH2:9][O:8]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 12676751HCID 12676751, compound

Product 1

HCID 45122716HCID 45122716, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

As described for example 112a, (2-oxo-oxazolidin-3-yl)-acetic acid ethyl ester (Potts, Kevin T.; Bhattacharjee, Debkumar; Kanemasa, Shuji. Journal of Organic Chemistry (1980), 45(24), 4985-8) in ethanol was reacted with hydrazine hydrate (1.0 equivalent) at rt for 72 h. All volatiles were evaporated, the residue was chromatographed (SiO2, dichloromethane:methanol:aq.ammonia (25%)=90:10:1) and the title compound was obtained as a white solid (yield: 77%). MS: m/e=160.4 [M+H]+.

Workup

  1. customAll volatiles were evaporated
  2. customthe residue was chromatographed (SiO2, dichloromethane:methanol:aq.ammonia (25%)=90:10:1)

Sources & evidence

ORD record
ord-18a74b86c985445bbe1810535f597593
Source dataset
uspto-grants-2009_03
Patent number
US07507729B2

Reaction notes

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