関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | 2-Chloro-5-methoxyanilinium chloride | HCID 2723900 | — |
| 反応物 | Potassium cyanate | HCID 11378442 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | (2-Chloro-5-methoxyphenyl)urea | HCID 21093757 | 81.1% |
反応手順
2-Chloro-5-methoxyaniline hydrochloride (26 g, 134 mmol) was added to acetic acid (117 ml) and water (13 ml). The slurry was warmed to 30° C. A solution of potassium cyanate (13 g, 161 mmol) in water (104 ml) was added dropwise. After 1 hour at 40° C., the reaction was cooled to 20° C., filtered and washed with water (78 ml). The product was dried overnight in vacuo at 60° C. to yield the title compound as a white solid (21.8 g, 81%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07507742B2 |
|---|
| 出典データセット | uspto-grants-2009_03 |
|---|
| ORD ID | ord-720b28c5db0f4890a338ebe8e375c616 |
|---|
| 出典メモ | uspto-grants-2009_03 |
|---|
