反应详情

温度

30 °C

2-Chloro-5-methoxyaniline hydrochloride (26 g, 134 mmol) was added to acetic acid (117 ml) and water (13 ml). The slurry was warmed to 30° C. A solution of potassium cyanate (13 g, 161 mmol) in water (104 ml) was added dropwise. After 1 hour at 40° C., the reaction was cooled to 20° C., filtered and washed with water (78 ml). The product was dried overnight in vacuo at 60° C. to yield the title compound as a white solid (21.8 g, 81%).

1. temperaturethe reaction was cooled to 20° C.
2. filtrationfiltered
3. washwashed with water (78 ml)
4. customThe product was dried overnight in vacuo at 60° C.