Methyl iodide → HCID 11179318, compound

HRID 1786289Notes

Reaction equation

[CH2:1]([C:8]([OH:26])([CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH:9]=[C:10]1[CH2:16][CH:15]2[N:17]([CH3:18])[CH:12]([CH2:13][CH2:14]2)[CH2:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:27][I:28]>>[I-:28].[CH2:19]([C:8]([OH:26])([CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[CH:9]=[C:10]1[CH2:16][CH:15]2[N+:17]([CH3:27])([CH3:18])[CH:12]([CH2:13][CH2:14]2)[CH2:11]1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 11268041HCID 11268041, compound

Product 1

HCID 11179318HCID 11179318, compound

Procedure

The title compound was prepared from 2-benzyl-1-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-ylidene)-3-phenyl-propan-2-ol and methyliodide by following the experimental procedures in Example 4 (85% yield): LCMS (ES) m/z 346 (M+H)+; 1H-NMR(CDCl3) δ 0.80 (m, 1H), 1.48 (m, 1H), 1.84 (m, 1H), 1.99 (m, 1H), 2.09 (m, 2H), 2.87 (m, 1H), 2.95 (m, 5H), 3.16 (s, 3H), 3.26 (s, 3H), 4.16 (m, 1H), 4.18 (m, 1H), 5.42 (s, 1H), 7.26 (m, 10H).

Sources & evidence

ORD record: ord-587843cf6e104bbc853af7ec7ec04ed5
Source dataset: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07507747B2

Reaction notes

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