Methyl iodide → HCID 11374612, compound

HRID 1786290Notes

Reaction equation

[CH3:1][N:2]1[CH:7]2[CH2:8][CH2:9][CH:3]1[CH2:4][C:5](=[CH:10][C:11]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[OH:12])[CH2:6]2.[CH3:25][I:26]>>[I-:26].[OH:12][C:11]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH:10]=[C:5]1[CH2:4][CH:3]2[N+:2]([CH3:25])([CH3:1])[CH:7]([CH2:8][CH2:9]2)[CH2:6]1

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 11393014HCID 11393014, compound

Product 1

HCID 11374612HCID 11374612, compound

Procedure

The title compound was prepared from 2-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-ylidene)-1,1-diphenyl-ethanol and methyliodide by following the experimental procedures in Example 4 (67% yield): LCMS (ES) m/z 334 (M+H)+; 1H-NMR(CDCl3) δ 1.50 (m, 1H), 1.98 (m, 1H), 2.11 (m, 1H), 2.35 (m, 2H), 2.87 (m, 1H), 2.96 (m, 1H), 3.23 (m, 1H), 3.27 (s, 3H), 3.56 (s, 3H), 4.00 (m, 1H), 4.28 (m, 1H), 6.49 (s, 1H), 7.35 (m, 8H), 7.49 (m, 2H).

Sources & evidence

ORD record: ord-2c9484adda5b465bba157e391c1695b8
Source dataset: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07507747B2

Reaction notes

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