Trifluoroacetic acid → Trifluoroacetic acid

Participants

Reaction Steps

To a solution of tert-butyl 3-[4-(5-chloro-7-cycloheptyl [1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-3,5-difluorophenoxy]propyl(methyl)carbamate (452 mg, 0.82 mmol) in 4 mL of methylene chloride is added 2.3 mL of trifluoroacetic acid. The mixture is stirred at room temperature for 18 h, and concentrated in vaccuo, yielding 3-[4-(5chloro-7-cycloheptyl[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-3,5-difluorophenoxy]-N-methylpropan-1-amine as a trifluoroacetic acid salt as a yellow semi-solid (400 mg). MS: m/z 450.2 (M+H).

Provenance & Evidence