Trifluoroacetic acid → Trifluoroacetic acid

HRID 1786310Notes

Reaction equation

HRID 1786310 reaction equation
[Cl:1][C:2]1[C:7]([C:8]2[C:26]([F:27])=[CH:25][C:11]([O:12][CH2:13][CH2:14][CH2:15][N:16](C)[C:17](=O)OC(C)(C)C)=[CH:10][C:9]=2[F:28])=[C:6]([CH:29]2[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]2)[N:5]2[N:36]=[CH:37][N:38]=[C:4]2[N:3]=1.[F:39][C:40]([F:45])([F:44])[C:41]([OH:43])=[O:42]>C(Cl)Cl>[Cl:1][C:2]1[C:7]([C:8]2[C:26]([F:27])=[CH:25][C:11]([O:12][CH2:13][CH2:14][CH2:15][NH:16][CH3:17])=[CH:10][C:9]=2[F:28])=[C:6]([CH:29]2[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35]2)[N:5]2[N:36]=[CH:37][N:38]=[C:4]2[N:3]=1.[F:39][C:40]([F:45])([F:44])[C:41]([OH:43])=[O:42]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86597652HCID 86597652, compound

Product 2

HCID 6422Trifluoroacetic acidHCID 11362915HCID 11362915, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl 3-[4-(5-chloro-7-cycloheptyl [1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-3,5-difluorophenoxy]propyl(methyl)carbamate (452 mg, 0.82 mmol) in 4 mL of methylene chloride is added 2.3 mL of trifluoroacetic acid. The mixture is stirred at room temperature for 18 h, and concentrated in vaccuo, yielding 3-[4-(5chloro-7-cycloheptyl[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-3,5-difluorophenoxy]-N-methylpropan-1-amine as a trifluoroacetic acid salt as a yellow semi-solid (400 mg). MS: m/z 450.2 (M+H).

Workup

  1. concentrationconcentrated in vaccuo

Sources & evidence

ORD record
ord-94fdb62393a8470388014bda6354dcec
Source dataset
uspto-grants-2009_03
Patent number
US07507739B2

Reaction notes

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