HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 2-(3-Nitro-5-trifluoromethyl-phenoxymethyl)-pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 1-Boc-2-(3-nitro-5-trifluoromethyl-phenoxymethyl)-pyrrolidine | HCID 21959386 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(3-Nitro-5-trifluoromethyl-phenoxymethyl)-pyrrolidine | HCID 21959418 | — |
Reaction Steps
1-Boc-2-(3-nitro-5-trifluoromethyl-phenoxymethyl)-pyrrolidine (2.35 g) was dissolved in CH2Cl2 (60 ml) and TFA (20 ml) was added. After stirring for 1 h at RT, the mixture was concentrated in vacuo to yield 2-(3-nitro-5-trifluoromethyl-phenoxymethyl)-pyrrolidine as an oil that solidified upon standing. The material was used as is without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07507748B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-5acee4ef974a4b6c981b26380a571c62 |
| Source note | uspto-grants-2009_03 |