Trifluoroacetic acid → 2-(3-Nitro-5-trifluoromethyl-phenoxymethyl)-pyrrolidine

HRID 1786320Notes

Reaction equation

HRID 1786320 reaction equation
C([N:8]1[CH2:12][CH2:11][CH2:10][CH:9]1[CH2:13][O:14][C:15]1[CH:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:18]=[C:17]([N+:25]([O-:27])=[O:26])[CH:16]=1)(OC(C)(C)C)=O.C(O)(C(F)(F)F)=O>C(Cl)Cl>[N+:25]([C:17]1[CH:16]=[C:15]([CH:20]=[C:19]([C:21]([F:24])([F:22])[F:23])[CH:18]=1)[O:14][CH2:13][CH:9]1[CH2:10][CH2:11][CH2:12][NH:8]1)([O-:27])=[O:26]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 21959386HCID 21959386, compound

Product 1

HCID 219594182-(3-Nitro-5-trifluoromethyl-phenoxymethyl)-pyrrolidine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1-Boc-2-(3-nitro-5-trifluoromethyl-phenoxymethyl)-pyrrolidine (2.35 g) was dissolved in CH2Cl2 (60 ml) and TFA (20 ml) was added. After stirring for 1 h at RT, the mixture was concentrated in vacuo to yield 2-(3-nitro-5-trifluoromethyl-phenoxymethyl)-pyrrolidine as an oil that solidified upon standing. The material was used as is without further purification.

Workup

  1. concentrationthe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-5acee4ef974a4b6c981b26380a571c62
Source dataset
uspto-grants-2009_03
Patent number
US07507748B2

Reaction notes

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