1-Methylpiperazine → HCID 21959580, compound

HRID 1786355Notes

Reaction equation

HRID 1786355 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:6]=1[Br:14])([CH3:4])([CH3:3])[CH3:2].[CH3:15][N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>>[Br:14][C:6]1[C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])=[CH:10][C:9]([N:19]2[CH2:20][CH2:21][N:16]([CH3:15])[CH2:17][CH2:18]2)=[C:8]([N+:11]([O-:13])=[O:12])[CH:7]=1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 2385872-Bromo-1-tert-butyl-4-nitrobenzene

Product 1

HCID 21959580HCID 21959580, compound

Conditions

Temperature
130 °C

Procedure

A mixture of 1-(tert-butyl)-2-bromo-4-nitrobenzene (3 g) and N-methylpiperazine (8 g) was heated neat at 130° C. for 4 h. The residue was purified by column chromatography to give 1-[4-bromo-5-(tert-butyl)-2-nitrophenyl]-4-methylpiperazine, which was hydrogenated to furnish 4-(tert-butyl)-2-(4-methylpiperazinyl)-phenylamine.

Workup

  1. customThe residue was purified by column chromatography

Sources & evidence

ORD record
ord-cd637d6bf2b4458493c8bead9ac43302
Source dataset
uspto-grants-2009_03
Patent number
US07507748B2

Reaction notes

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