反应详情

A mixture of 1-acetyl-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile (0.872 g, step D), 10% Pd/C (0.882 g), 20 mL of Et3N, and 80 mL of EtOH was stirred at RT under balloon pressure of H2 for overnight. Solid was removed by filtration through a pad of Celite® and the filtrate was concentrated to yield a cream color residue, which was purified by chromatography through silica gel (70 g, 2 to 5% MeOH/CHCl3 with 1% NH4OH) to afford 1-(4-aminomethyl-pyrrolo[2,3-b]pyridin-1-yl)-ethanone as a white solid.

1. customSolid was removed by filtration through a pad of Celite®
2. concentrationthe filtrate was concentrated
3. customto yield a cream color residue, which
4. customwas purified by chromatography through silica gel (70 g, 2 to 5% MeOH/CHCl3 with 1% NH4OH)