1-Piperazinecarboxylic acid, ethyl ester → 4-[5-(1-Isopropyl-piperidin-4-yloxy)-6-methyl-1H-indole-2-carbonyl]-piperazine-1-carboxylic acid ethyl ester
Reaction equation
Cl.[CH:2]([N:5]1[CH2:10][CH2:9][CH:8]([O:11][C:12]2[CH:13]=[C:14]3[C:18](=[CH:19][C:20]=2[CH3:21])[NH:17][C:16]([C:22]([OH:24])=O)=[CH:15]3)[CH2:7][CH2:6]1)([CH3:4])[CH3:3].[CH2:25]([O:27][C:28]([N:30]1[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1)=[O:29])[CH3:26]>>[CH2:25]([O:27][C:28]([N:30]1[CH2:31][CH2:32][N:33]([C:22]([C:16]2[NH:17][C:18]3[C:14]([CH:15]=2)=[CH:13][C:12]([O:11][CH:8]2[CH2:7][CH2:6][N:5]([CH:2]([CH3:3])[CH3:4])[CH2:10][CH2:9]2)=[C:20]([CH3:21])[CH:19]=3)=[O:24])[CH2:34][CH2:35]1)=[O:29])[CH3:26]Participants
3
Procedure
The title compound was synthesized in analogy to example 1, from 5-(1-isopropyl-piperidin-4-yloxy)-6-methyl-1H-indole-2-carboxylic acid hydrochloride and 1-ethoxycarbonylpiperazine to afford the title compound as a light-yellow foam (65%).
Sources & evidence
- ORD record
- ord-dd0394a8216149ca803701f59b103fc6
- Source dataset
- uspto-grants-2009_03
- Patent number
- US07507736B2
Reaction notes
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