HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Piperazinecarboxylic acid, ethyl ester → 4-[5-(1-Isopropyl-piperidin-4-yloxy)-6-methyl-1H-indole-2-carbonyl]-piperazine-1-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Piperazinecarboxylic acid, ethyl ester | HCID 8431 | — |
| Reactant | 5-(1-isopropyl-piperidin-4-yloxy)-6-methyl-1H-indole-2-carboxylic acid hydrochloride | HCID 68563636 | — |
| Product | 4-[5-(1-Isopropyl-piperidin-4-yloxy)-6-methyl-1H-indole-2-carbonyl]-piperazine-1-carboxylic acid ethyl ester | HCID 68566846 | 65% |
Reaction Steps
The title compound was synthesized in analogy to example 1, from 5-(1-isopropyl-piperidin-4-yloxy)-6-methyl-1H-indole-2-carboxylic acid hydrochloride and 1-ethoxycarbonylpiperazine to afford the title compound as a light-yellow foam (65%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07507736B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-dd0394a8216149ca803701f59b103fc6 |
| Source note | uspto-grants-2009_03 |