Cyclopropanecarbonyl chloride → HCID 68566455, compound

HRID 1786501Notes

Reaction equation

Cl.[CH:2]([N:5]1[C:13]2[C:8](=[CH:9][C:10]([O:14][CH:15]3[CH2:20][CH2:19][N:18]([CH:21]([CH3:23])[CH3:22])[CH2:17][CH2:16]3)=[CH:11][CH:12]=2)[CH:7]=[C:6]1[C:24]([N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1)=[O:25])([CH3:4])[CH3:3].[CH:32]1([C:35](Cl)=[O:36])[CH2:34][CH2:33]1>>[CH:32]1([C:35]([N:29]2[CH2:28][CH2:27][N:26]([C:24]([C:6]3[N:5]([CH:2]([CH3:3])[CH3:4])[C:13]4[C:8]([CH:7]=3)=[CH:9][C:10]([O:14][CH:15]3[CH2:20][CH2:19][N:18]([CH:21]([CH3:23])[CH3:22])[CH2:17][CH2:16]3)=[CH:11][CH:12]=4)=[O:25])[CH2:31][CH2:30]2)=[O:36])[CH2:34][CH2:33]1

Participants

Reactant 2

HCID 77637Cyclopropanecarbonyl chloride

HCID 68565609HCID 68565609, compound

Product 1

HCID 68566455HCID 68566455, compound

Procedure

The title compound was prepared in analogy to example 51, from [1-isopropyl-5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-piperazin-1-yl-methanone hydrochloride and cyclopropanoyl chloride. Light-yellow solid. MS (m/z): 481.5 (M+H)+.

Sources & evidence

ORD record: ord-eb1cc6f7607f4d44ac6677ec2084b722
Source dataset: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07507736B2

Reaction notes

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