Methyl piperazine-1-carboxylate → 4-{5-[1-(2,2,2-Trifluoro-ethyl)-piperidin-4-yloxy]-1H-indole-2-carbonyl]-piperazine-1-carboxylic acid methyl ester
Reaction equation
[F:1][C:2]([F:24])([F:23])[CH2:3][N:4]1[CH2:9][CH2:8][CH:7]([O:10][C:11]2[CH:12]=[C:13]3[C:17](=[CH:18][CH:19]=2)[NH:16][C:15]([C:20]([OH:22])=O)=[CH:14]3)[CH2:6][CH2:5]1.[N:25]1([C:31]([O:33][CH3:34])=[O:32])[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>>[CH3:34][O:33][C:31]([N:25]1[CH2:30][CH2:29][N:28]([C:20]([C:15]2[NH:16][C:17]3[C:13]([CH:14]=2)=[CH:12][C:11]([O:10][CH:7]2[CH2:6][CH2:5][N:4]([CH2:3][C:2]([F:23])([F:1])[F:24])[CH2:9][CH2:8]2)=[CH:19][CH:18]=3)=[O:22])[CH2:27][CH2:26]1)=[O:32]Participants
3
Procedure
The title compound was prepared in analogy to example 40b), from 5-[1-(2,2,2-trifluoro-ethyl)-piperidin-4-yloxy]-1H-indole-2-carboxylic acid and methyl piperazine-1-carboxylate. Light yellow solid. MS (m/z): 469.3 (M+H)+.
Sources & evidence
- ORD record
- ord-63c3ca63d3ed41baa0d4b9fe576da2ca
- Source dataset
- uspto-grants-2009_03
- Patent number
- US07507736B2
Reaction notes
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