HCID 131727367, compound → HCID 57597585, compound

HRID 1786537Notes

Reaction equation

HRID 1786537 reaction equation
C([N:9]1[CH2:13][CH2:12][CH:11]([N:14]([CH3:36])[C:15](=[O:35])[CH2:16][CH2:17][CH2:18][CH2:19][CH:20]([C:28]2[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=2)[C:21]2[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=2)[CH2:10]1)(=O)C1C=CC=CC=1>CO.[Pd]>[CH3:36][N:14]([C@@H:11]1[CH2:12][CH2:13][NH:9][CH2:10]1)[C:15](=[O:35])[CH2:16][CH2:17][CH2:18][CH2:19][CH:20]([C:21]1[CH:22]=[CH:23][C:24]([F:27])=[CH:25][CH:26]=1)[C:28]1[CH:29]=[CH:30][C:31]([F:34])=[CH:32][CH:33]=1

Participants

4

Reactant 1

HCID 131727367HCID 131727367, compound

Product 1

HCID 57597585HCID 57597585, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 6,6-Bis-(4-fluoro-phenyl)-hexanoic acid(1-benzoyl-pyrrolidin-3-yl)-methyl amide(1.0 g, 2.1 mmol in CH3OH (50 ml) was added Pd/C 20% (250 mg). The resulting slurry was hydrogenated at 50 psi for 24 hours. The catalyst was filtered through Celite and filtrate evaporated under reduced pressure to give 0.78 g of desired product.

Workup

  1. filtrationThe catalyst was filtered through Celite and filtrate
  2. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-dc32dab8144d4f6a9059963a3961787d
Source dataset
uspto-grants-2009_03
Patent number
US07507760B2

Reaction notes

Loading…